By: lovingitall0
23 Sep 2004, 09:14 AM EDT
Msg. 168610 of 170503
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Good Morning: AVR118 and Peptide Nucleic Acid Complexes

A couple of years ago, I remember reading on one of the ADVR Message Boards a post by someone that impressed me very much.

As the author discussed the important potential of Product R/AVR118 as an AIDS treatment, he mentioned there was also the excitement being generated as what he referred to as "The New Biology".

The writer went into how Peptide Nucleic Acid Complexes are part of our growing understanding of the importance of anti-sense regulation of specific gene signals and that the one "who can block the receptor first" issue really isn't that important in the overall scheme of things, but that the ability to "turn off or on" a genetic signal using this technology is incredibly seminal to reversing and curing disease...since most disease is either infectious as a promoter or inflammatory as a modulator, the New Biology...our understanding of genetic mapping and signals will lead to the New Therapeutics, agents which will interrupt the message that cause cellular damage.

The writer also believed that Product R [now AVR118] will do this, and that we would be applying these Peptide Nucleic Acids to cancer, autoimmune diseases, MS, RA, and a host of others.

This is exactly what I see we are accomplishing today.

Dr. Hirschman's knowledge of science was years ahead of many others in his field. He had a vision of the potential of Reticulose/ AVR118 and now it's all coming together.

So, no, I can't agree with anyone who says that we're not a PNA and have nothing to do with anti-sense.

Read Dr. James T. D'Olimpio's AVR118 abstract presentation entitled "Use of a Peptide Nucleic Acid Complex in Cancer
Regulation and Metastasis at 1st ISC International Conference on Cancer Therapeutics Molecular Targets in Florence, Italy.

Read The presentation on 'Anti-Cachectic Effects of a Novel Peptide Nucleic Acid Complex: AVR118, Preliminary Results of a Phase1/2 Clinical Trial, ' given by Dr. James T. D'Olimpio at The American Society of Clinical Oncology's (ASCO) 40th Annual Meeting in New Orleans, LA.

Listen to the great interviews again on the ADVR website.

Mindless Barry can call me anything he wants to, and he does, but he's not the sharpest pencil in the box and that's obvious by his actions. He just can't stand anyone's opinion on anything but his own.

Well, this is mine.


By: SUE32073
23 Sep 2004, 10:14 AM EDT
Msg. 168611 of 170504
(This msg. is a reply to 168610 by lovingitall0.)
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lovie, I think I know who the writer was you are referring to. I think he also mentioned he was going to go work with Dr. Hirschman. As far as your disagreement with Mind concerning PNA complexes (switch on swith off theory) - I cannot honestly say who is right and who is wrong. I just don't know. What I do know's been a mighty long time and some of us shareholders have become mighty discouraged with the flip-flopping of management's ability to handle "this proclaimed mighty PNA drug currently known as AVR118." Obviously, some here have (let's just say) fallen out of love with what we once believed to be "the wonder drug" (as Bernie put it).

If as you say....."This is exactly what I see we are accomplishing today" concerning Dr. Hirschman's "vision" -- then that's all find and good. But, all this vision and all this PNA stuff has yet to be proven!

Sorry, but my vision of Dr. Hirschman's "vision" is very, very clouded.

I hope I am wrong!
By: lovingitall0
23 Sep 2004, 11:05 AM EDT
Msg. 168614 of 170504
(This msg. is a reply to 168611 by SUE32073.)
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Sue, it's difficult to say who the writer was expressing these thoughts because there were several excellent posters on different ADVR message boards and I looked for their insights constantly. It was an education and a pleasure to read those worthwhile and very well written contributions.

We have a couple of very good posters on this forum also. Unfortunately they get lost in the minutia of daily nonsense and I can see why they don't show up very often.

No one is denying the errors of past management. I just believe it serves no purpose and is counterproductive to harp on what was, and prefer to concentrate on what is at present. I feel we have an excellent team now headed by a very experienced CEO in Dr. Elma Hawkins.

ADVR has been around for many years and it's been a long hard road for all shareholders as we see our investment dwindle down to these levels. We have to climb up the staircase again one step at a time just to reach where we came in at, and then walk up higher and closer to the top landing. That will take several more years and then several more after that.

Time will tell and I do have that, along with my faith and belief in AVR118 which is still unwavering.

As long as I have my money invested in this Company, I'll always be a staunch supporter.


By: lovingitall0
23 Sep 2004, 12:47 PM EDT
Msg. 168616 of 170504
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(Any good cookie recipes???) Cannabis May Help Combat Cancer-Causing Herpes Viruses


Source: University of South Florida Health Sciences Center

The compound in marijuana that produces a high, delta-9 tetrahydrocannbinol or THC, may block the spread of several forms of cancer causing herpes viruses, University of South Florida College of Medicine scientists report.
The findings, published Sept. 15 in the online journal BMC Medicine, could lead to the creation of antiviral drugs based on nonpsychoactive derivatives of THC.

The gamma herpes viruses include Kaposi's Sarcoma Associated Herpes virus, which is associated with an increased risk of cancer that is particularly prevalent in AIDS sufferers. Another is Epstein-Barr virus, which predisposes infected individuals to cancers such as Burkitt's lymphoma and Hodgkin's disease.

Once a person is infected, these viruses can remain dormant for long periods within white blood cells before they burst out and begin replicating. This reactivation of the virus boosts the number of cells infected thereby increasing the chances that the cells will become cancerous.

The USF team, led by virologist Peter Medveczky, MD, found that this sudden reactivation was prevented if infected cells were grown in the presence of THC. While cells infected with a mouse gamma herpes virus normally died when the virus was reactivated, these same cells survived when cultured in the laboratory along with the cannabinoid compound further evidence that THC prevents viral reactivation.

Furthermore, the researchers showed that THC acts specifically on gamma herpes viruses. The chemical had no effect on another related virus, herpes simplex-1, which causes cold sores and genital herpes.

Small concentrations of THC were more potent and selective against gamma herpes viruses than the commonly used antiviral drugs acyclovir, gancicyclovir and foscamet, said Dr. Medveczky, a professor in the Department of Medical Microbiology and Immunology.

The USF researchers suggest that THC selectively inhibits the spread of gamma herpes viruses by targeting a gene these viruses all share called ORF50.

By: lovingitall0
23 Sep 2004, 04:59 PM EDT
Msg. 168649 of 170507
(This msg. is a reply to 168647 by yanks04.)
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Yanks, any thoughts re PNA's and anti-sense activities?
By: yanks04
23 Sep 2004, 05:14 PM EDT
Msg. 168650 of 170507
(This msg. is a reply to 168649 by lovingitall0.)
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I think Peptides are completely different compared to a Peptide--Nucleic Acid. That's obvious.